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2024-02-15 08:47:17

This https://arxiv.org/abs/2312.05785 has been replaced.
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On Possible Indicators of Negative Selection in Germinal Centers
A central feature of vertebrate immune response is affinity maturation, wherein antibody-producing B cells undergo evolutionary selection in microanatomical structures called germinal centers, which form in secondary lymphoid organs upon antigen exposure. While it has been shown that the median B cell affinity dependably increases over the course of maturation, the exact logic behind this evolution remains vague. Three potential selection methods include encouraging the reproduction of high aff…